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Could this be the result of the high oxidation in the body mutating
the bacteria like has been shown to happen?

"Simple sore throat bacteria had mutated"

http://news.bbc.co.uk/1/hi/health/3930727.stm

Mystery of the forgotten plague

Brain samples were tested
Just a few months ago, a paper was published, with very little
fanfare, in an obscure medical journal.
But the contents of the paper were astonishing. In it was a potential
solution to what has been called the biggest medical mystery of all
time.

Two young doctors had tracked down the probable cause of one of the
most baffling epidemics of the 20th Century - a disease called
Encephalitis Lethargica.

Encephalitis Lethargica was a devastating illness that swept the world
in the 1920's.

It attacked the brain, leaving victims like living statues, speechless
and motionless.

During the outbreak, nearly a million died, and millions more were
left frozen inside their useless bodies, in institutions.

No-one knew what had caused it, or how to treat it.

Reppearance

For virologist Professor John Oxford, the disease was not just a
disease of the past. As an expert on the condition, he was convinced
that it could reappear.


Professor Oxford could not find the cause
"I certainly do think that whatever caused it could strike again. And
until we know what caused it we won't be able to prevent it happening
again."

And in 1993, it seemed his fears were being realised.

Becky Howells was 23 years old, when she suddenly became very ill. She
started shaking, becoming feverish, hallucinating.

Within hours she had become critically ill and was rushed to hospital.
Doctors had no idea what was wrong.

They knew her brain was dangerously inflamed, but had no idea what was
causing it.

Her doctor Stavia Blunt said: "I was shocked by her appearance,
stunned. She had these very bizarre clawing movements of her arms. It
was weird."

Her father Tom prepared himself for the worst.

"I said goodbye. I said goodbye at the resuscitation unit, because I
didn't think I'd see her again," he said.

Astonishing conclusion

As doctors battled to save her life they were forced to an incredible
conclusion.

Becky was suffering from Encephalitis Lethargica - a disease that had
last appeared over 70 years before. And it was just as baffling now as
it was then.

Professor Oxford was convinced that the solution lay in the past. He
tracked down brain tissue samples from the original 1920 victims and
tested them, looking for traces of a virus that could have been
responsible for the outbreak all those years ago.

At the time, an unusually severe strain of influenza, Spanish flu, had
swept the world, and it seemed possible that both epidemics were
linked.

But despite exhaustive testing with the latest molecular probes, there
was no evidence of any virus - flu or anything else.

Becky gradually recovered, but it was two years before she could
restart her life.

More cases

And Becky was not an isolated case. Since then more and more patients
have been discovered. All suffering from the same bizarre symptoms.

Patricia Vaughan, was an energetic, active woman when she was struck
down with the mysterious illness four years ago.

Sadly, she did not make a full recovery and now needs full time care
from her partner, Geoff Shillington.

"It's very hard, because no-one can help you and you're just sitting
there watching somebody going downhill, and you can't do a thing about
it," he said.

At Great Ormond Street Hospital, one young doctor, Dr Russell Dale was
alarmed that the disease was more common than he had ever realised.

He started tracking down other similar cases. Word got round the
medical community and colleagues began referring their own cases to
him.

Gradually he build up a case load of over 20 patients - all with
Encephalitis lethargica.

At this stage, the disease was still a complete mystery. Noone had any
idea what might be causing it - or, more worryingly, how to treat it.

Analysis

Together with a colleague, Dr Andrew Church, the two doctors began
analysing all their patients to see if they had anything in common.

We realised we must be onto something

Dr Andrew Church
The first clue was that many of the patients had had a sore throat
before they were struck down with the illness.

So the two doctors started looking for evidence of bacterial infection
- and particularly streptococcus bacteria which is a common cause of
sore throats.

"It was amazing really and very exciting, when the first results came
back," said Dr Church.

"We got first one, then two, then ten...then all the patients had the
same result. So we realised we must be onto something."

They had discovered evidence of a rare form of streptococcus bacteria
in all their patients.

The bacteria that can cause a simple sore throat had mutated into a
much more severe form and triggered the attacks of encaphilitis
lethargica.

Immune reaction

It seems that in some people the body has a massive immune reaction to
the streptococcus bacteria and then turns on the body itself;
attacking the brain and destroying it.

It was an astonishing discovery. But that was not the full story.

Dr Church as keen to see if there was any evidence to suggest that
this might also have been the cause of the 1920 epidemic all those
years ago.

Dr Dale went back to the original medical records of the time. And as
he pored over the reports, he discovered two very telling pieces of
evidence.

First, many of the original victims had also presented with sore
throats, and secondly, in the detail was a reference to a particular
bacteria - diplococcus. Diplococcus is a form of streptococcus
bacteria.

It was astonishing. There in the medical records was a description of
a bacterial infection very similar to the one causing the modern cases
of Encephalitis Lethargica.

For Dr Dale and Dr Church it was a very exciting moment. Not only had
they identified the cause of the modern cases, they may have finally
cracked an 80-year-old medical mystery.


Medical Mysteries: The Forgotten Plague was broadcast on BBC One on 28
July at 2235 BST.


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