Subject: Re: asking again about melatonin
Author: kaptanDate: 18 Aug
Ref:
You must ALWAYS ask your doctor if it relates to treatment but if you want
to collect data for information purposes this will get you started:
http://www.wright.edu/admin/fredwhite/pharmacy/popular_nremedies5.html
Try googling:
- prozac melatonin contraindications
- prozac melatonin reactions
- prozac drug interactions/ contraindications
Then when you find some stuff you will encounter additional key words to
conduct a less specific search - the above link would give you:
- serotonin reuptake inhibitors melatonin
- serotonin syndrome
- antidepressants melatonin
These are good sites but somewhat technical
http://www.medscape.com/
http://www.emedicine.com/
Pubmed http://www.ncbi.nlm.nih.gov/sites/entrez
Drug reference http://search.medscape.com/drug-reference-search
Drug interaction checker
http://www.medscape.com/druginfo/druginterchecker?cid=med
Drug interactions checker http://www.drugs.com/drug_interactions.php
Medical University sites and large hospital clinics quite often have less
technical jargon.
This is from Drugs.com:
Drug interaction results for the following 2 drug(s):
Melatonin
Prozac (fluoxetine)
Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions
exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
. There are 27 other drugs known to interact with Melatonin
. There are 1812 other drugs known to interact with Prozac (fluoxetine)
Interactions between your selected drugs and food
Melatonin (Minor Drug-Food)
Oral caffeine may significantly increase the bioavailability of melatonin.
The proposed mechanism is inhibition of CYP450 1A2 first-pass metabolism.
After administration of melatonin 6 mg and caffeine 200 mg orally
(approximately equivalent to 1 large cup of coffee) to 12 healthy subjects,
the mean peak plasma concentration (Cmax) of melatonin increased by 137% and
the area under the concentration-time curve (AUC) increased by 120%. The
metabolic inhibition was greater in nonsmokers (n=6) than in smokers (n=6).
The greatest effect was seen in subjects with the *1F/*1F genotype (n=7),
whose melatonin Cmax increased by 202%. The half-life did not change
significantly. The clinical significance of this interaction is unknown.
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